Lee Yeong Oh is a genius neurosurgeon who just came back to Korea after finishing his studies abroad. He now works with his father, Lee Gun Myung, who is the head of the cardio-cerebrovascular center at Hyunsung hospital. However, Yeong Oh lacks empathy towards his patients due to his antisocial personality disorder. One day, traffic policewoman Gye Jin Sung sees a murder in front of her, which was disguised as a traffic accident. She rushes the victim to Hyunsung hospital, where her crush Surgeon Hyun Suk Joo, of the cardiothoracic section, and Surgeon Yeong Oh operate on him. Unfortunately, the patient dies and she starts suspecting Surgeon Yeong Oh of foul play. Meanwhile, a series of bizarre patient deaths start occurring at the hospital and Yeong Oh starts investigating it.