Both brothers and rivals, Kim Su Hyung (Jang Dong Gun) and Kim Jun Ki (Son Chang Min) are doctors at the same hospital. Young and promising figures in the field, Su Hyung and Jun Ki are dedicated to their profession, though not always as disciplined in other matters. Su Hyung's rash and insensitive personality often brings tears to his longtime girlfriend Min Joo (Lee Young Ae), who is also a doctor. The brothers face crises in both their personal and professional lives when Jun Ki's mistake leads to his friend's wife's passing and Su Hyung discovers a family secret concerning his identity.