On his wedding anniversary, Han Chul-min (Jang Hyuk) drives into his apartment complex parking lot and sees a large crowd gathered by the entryway into his apartment. He enters holding a bouquet of flowers for his wife, instead he finds police officers scattered about collecting evidence. In his bedroom there is a large pool of blood dripping onto the floor from the bed, and his wife is nowhere to be seen. Han is then handcuffed, arrested and taken into police custody for her murder. Prosecutor Ahn Min-ho (Park Hee-soon) takes charge of prosecuting the Han murder case. He has little doubt in the guilt of Chul-min. Confirming his suspicions that Han was arrested as the prime suspect in a serial murder case, but later released on insufficient evidence. Jang Ho-won (Sung Dong-il), an investigator, brings the case of Han to defense lawyer Kang Sung-hee (Ha Jung-woo). He informs Kang that the alleged murder victim's body was never discovered, the police have yet to find any direct evidence connecting Han to the murder of his wife and his arrest is based on circumstantial evidence. Han, who works at a film laboratory, has no fingerprints as they are erased from the strong chemicals he handles everyday. Convinced that Han is not guilty, Kang takes the case and applies in court for a jury trial and goes through a series of legal clashes against rival prosecutor Ahn. The case gets even more complex as details about the mysterious life of Han's wife are unveiled.